The misfolded prion form of a protein can convert the properly folded version of the protein in an infected brain into the normal conformation. This allows the misfolded prions, which tend to form aggregates, to spread rapidly from cell to cell, eventually causing the death of the affected animal or human.
举一反三
- A part of protein sequence that can form a compact three-dimensional structure and often can be independently folded is called ______.
- The correct descriptions about prion are A: It is a normal component of mammalian brain cells. B: The secondary structure is rich in α-helices. C: The prions with structural variations can aggregate with each other to form amyloid fiber precipitation. D: The prions are viruses containing nucleic acids.
- Prions are considered “_________” because they can also spread from an affected individual to a normal individual via contaminated food, blood, or surgical instruments.
- GTP-binding proteins act as _______________: they are in their active conformation when GTP is bound, but they can hydrolyze this GTP to GDP, which releases a phosphate and flips the protein to an inactive conformation.
- which one doesn't form the human body A: cell B: tissue C: organ D: gill